IntOGen - CYP2C8 gene cancer mutations

CYP2C8 is detected as a mutational cancer driver

CYP2C8 reports

Methods
Mutation distribution

Gene details

CYP2C8
Ensembl ID ENSG00000138115 Transcript ID ENST00000371270 Protein ID ENSP00000360317
Cancer types where is driver 2 Cohorts where is driver 2 Mutated samples 13 Mutations 326
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence