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CRB1 has not been detected as a mutational cancer driver

CRB1
Ensembl id ENSG00000134376
Mutated samples
Coding Sequence 258 (3.8%)
Protein Affecting 179 (2.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CRB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 91 62 16.80
Lung adenocarcinoma No 28 23 5.88
Lung squamous cell carcinoma No 23 20 11.49
Head and neck squamous cell carcinoma No 24 15 4.00
Breast carcinoma No 11 8 0.70
Serous ovarian adenocarcinoma No 8 7 2.22
Colorectal adenocarcinoma No 7 7 3.06
Bladder carcinoma No 8 6 6.12
Renal clear cell carcinoma No 9 6 1.44
Small cell lung carcinoma No 7 6 8.70
Uterine corpus endometrioid carcinoma No 10 4 1.74
Stomach adenocarcinoma No 8 4 2.48
Esophageal carcinoma No 7 4 2.74
Non small cell lung carcinoma No 5 2 6.45
Glioblastoma multiforme No 2 2 0.53
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Prostate adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence