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CORIN has not been detected as a mutational cancer driver

CORIN
Ensembl id ENSG00000145244
Mutated samples
Coding Sequence 126 (1.9%)
Protein Affecting 91 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CORIN gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 47 36 9.76
Lung squamous cell carcinoma No 13 9 5.17
Lung adenocarcinoma No 10 8 2.05
Stomach adenocarcinoma No 9 6 3.73
Small cell lung carcinoma No 6 5 7.25
Colorectal adenocarcinoma No 6 4 1.75
Breast carcinoma No 4 3 0.26
Head and neck squamous cell carcinoma No 3 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 3 2 2.04
Uterine corpus endometrioid carcinoma No 3 2 0.87
Esophageal carcinoma No 5 2 1.37
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 1 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence