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COL7A1 has not been detected as a mutational cancer driver

COL7A1
Ensembl id ENSG00000114270
Mutated samples
Coding Sequence 231 (3.4%)
Protein Affecting 184 (2.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all COL7A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 74 63 17.07
Lung adenocarcinoma No 25 20 5.12
Breast carcinoma No 22 17 1.48
Lung squamous cell carcinoma No 16 14 8.05
Stomach adenocarcinoma No 18 13 8.07
Bladder carcinoma No 10 10 10.20
Uterine corpus endometrioid carcinoma No 15 9 3.91
Head and neck squamous cell carcinoma No 10 8 2.13
Prostate adenocarcinoma No 5 4 1.65
Renal clear cell carcinoma No 6 4 0.96
Serous ovarian adenocarcinoma No 6 4 1.27
Colorectal adenocarcinoma No 4 3 1.31
Glioblastoma multiforme No 3 3 0.79
Esophageal carcinoma No 5 3 2.05
Neuroblastoma No 3 2 0.95
Small cell lung carcinoma No 2 2 2.90
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence