IntOGen - COL6A6 gene cancer mutations in PAAD

COL6A6 is detected as a mutational cancer driver in Pancreatic Adenocarcinoma

COL6A6 reports in Pancreatic Adenocarcinoma (PAAD)

Methods
Mutation distribution

Cancer type details

Pancreatic Adenocarcinoma
Cohorts 7 Samples 922 Mutations 2,520,434 Driver genes 64

Gene details

COL6A6
Ensembl ID ENSG00000206384 Transcript ID ENST00000358511 Protein ID ENSP00000351310
Cohorts where is driver 1 Mutated samples 3 Mutated samples (%) 0.33 Mutations 21
Mode of action Loss of function
Known driver False

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence