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COG2 has not been detected as a mutational cancer driver

COG2
Ensembl id ENSG00000135775
Mutated samples
Coding Sequence 35 (0.5%)
Protein Affecting 23 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all COG2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 5 4 2.30
Cutaneous melanoma No 9 4 1.08
Bladder carcinoma No 3 3 3.06
Stomach adenocarcinoma No 3 3 1.86
Glioblastoma multiforme No 3 3 0.79
Breast carcinoma No 2 2 0.17
Lung adenocarcinoma No 3 1 0.26
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Head and neck squamous cell carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence