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CLOCK mutations in 5 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung squamous cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma, Glioblastoma multiforme

CLOCK
Ensembl id ENSG00000134852
Mutated samples
Coding Sequence 48 (0.7%)
Protein Affecting 35 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CLOCK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 8 5 1.36
Lung squamous cell carcinoma Yes 4 4 2.30
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Glioblastoma multiforme Yes 5 3 0.79
Stomach adenocarcinoma Yes 3 2 1.24
Head and neck squamous cell carcinoma No 6 5 1.33
Breast carcinoma No 3 2 0.17
Medulloblastoma No 2 2 0.95
Lung adenocarcinoma No 1 1 0.26
Hepatocarcinoma No 3 1 1.11
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence