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CHD5 has not been detected as a mutational cancer driver

CHD5
Ensembl id ENSG00000116254
Mutated samples
Coding Sequence 170 (2.5%)
Protein Affecting 115 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHD5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 54 38 10.30
Lung adenocarcinoma No 20 11 2.81
Breast carcinoma No 12 9 0.78
Lung squamous cell carcinoma No 10 8 4.60
Glioblastoma multiforme No 11 8 2.11
Uterine corpus endometrioid carcinoma No 9 6 2.61
Bladder carcinoma No 9 5 5.10
Prostate adenocarcinoma No 4 4 1.65
Renal clear cell carcinoma No 7 4 0.96
Stomach adenocarcinoma No 6 4 2.48
Hepatocarcinoma No 3 3 3.33
Serous ovarian adenocarcinoma No 3 3 0.95
Head and neck squamous cell carcinoma No 6 3 0.80
Esophageal carcinoma No 5 3 2.05
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Chronic lymphocytic leukemia No 1 1 0.34
Colorectal adenocarcinoma No 2 1 0.44
Pancreas adenocarcinoma No 2 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence