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CELSR3 has not been detected as a mutational cancer driver

CELSR3
Ensembl id ENSG00000008300
Mutated samples
Coding Sequence 183 (2.7%)
Protein Affecting 126 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CELSR3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 59 34 9.21
Uterine corpus endometrioid carcinoma No 15 12 5.22
Lung adenocarcinoma No 13 11 2.81
Bladder carcinoma No 11 10 10.20
Breast carcinoma No 12 9 0.78
Head and neck squamous cell carcinoma No 12 9 2.40
Stomach adenocarcinoma No 12 8 4.97
Serous ovarian adenocarcinoma No 9 6 1.90
Glioblastoma multiforme No 7 6 1.58
Lung squamous cell carcinoma No 7 5 2.87
Renal clear cell carcinoma No 4 4 0.96
Esophageal carcinoma No 7 4 2.74
Prostate adenocarcinoma No 2 2 0.82
Lower grade glioma No 3 2 1.18
Hepatocarcinoma No 4 1 1.11
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Colorectal adenocarcinoma No 2 1 0.44
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence