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CELSR2 has not been detected as a mutational cancer driver

CELSR2
Ensembl id ENSG00000143126
Mutated samples
Coding Sequence 151 (2.2%)
Protein Affecting 101 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CELSR2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 35 19 5.15
Head and neck squamous cell carcinoma No 19 12 3.20
Stomach adenocarcinoma No 15 11 6.83
Breast carcinoma No 10 9 0.78
Lung squamous cell carcinoma No 11 7 4.02
Uterine corpus endometrioid carcinoma No 11 7 3.04
Lung adenocarcinoma No 10 6 1.53
Esophageal carcinoma No 6 5 3.42
Renal clear cell carcinoma No 6 4 0.96
Serous ovarian adenocarcinoma No 4 4 1.27
Prostate adenocarcinoma No 4 3 1.23
Colorectal adenocarcinoma No 5 3 1.31
Bladder carcinoma No 4 2 2.04
Neuroblastoma No 3 2 0.95
Glioblastoma multiforme No 2 2 0.53
Medulloblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 2 1 1.45
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence