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CACNA1S has not been detected as a mutational cancer driver

CACNA1S
Ensembl id ENSG00000081248
Mutated samples
Coding Sequence 202 (3.0%)
Protein Affecting 135 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CACNA1S gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 79 49 13.28
Head and neck squamous cell carcinoma No 15 13 3.47
Breast carcinoma No 12 8 0.70
Glioblastoma multiforme No 10 8 2.11
Lung adenocarcinoma No 12 7 1.79
Renal clear cell carcinoma No 12 7 1.68
Lung squamous cell carcinoma No 9 6 3.45
Stomach adenocarcinoma No 8 6 3.73
Uterine corpus endometrioid carcinoma No 6 5 2.17
Serous ovarian adenocarcinoma No 6 5 1.58
Colorectal adenocarcinoma No 6 5 2.18
Lower grade glioma No 5 4 2.37
Small cell lung carcinoma No 5 4 5.80
Prostate adenocarcinoma No 2 2 0.82
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 5 1 1.02
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Esophageal carcinoma No 2 1 0.68
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence