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CACNA1E has not been detected as a mutational cancer driver

CACNA1E
Ensembl id ENSG00000198216
Mutated samples
Coding Sequence 355 (5.2%)
Protein Affecting 261 (3.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CACNA1E gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 117 83 22.49
Lung adenocarcinoma No 47 39 9.97
Breast carcinoma No 28 24 2.09
Uterine corpus endometrioid carcinoma No 21 16 6.96
Lung squamous cell carcinoma No 20 15 8.62
Stomach adenocarcinoma No 16 15 9.32
Head and neck squamous cell carcinoma No 19 14 3.73
Esophageal carcinoma No 9 8 5.48
Prostate adenocarcinoma No 11 7 2.88
Colorectal adenocarcinoma No 10 7 3.06
Glioblastoma multiforme No 7 6 1.58
Bladder carcinoma No 6 5 5.10
Serous ovarian adenocarcinoma No 6 4 1.27
Acute myeloid leukemia No 3 3 1.53
Thyroid carcinoma No 4 3 0.93
Lower grade glioma No 4 3 1.78
Renal clear cell carcinoma No 4 2 0.48
Multiple myeloma No 2 2 2.90
Small cell lung carcinoma No 2 2 2.90
Pancreas adenocarcinoma No 2 1 0.47
Neuroblastoma No 1 1 0.48
Diffuse B cell lymphoma No 2 1 4.35
Hepatocarcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 8 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence