BMPR2 mutations in 10 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Bladder carcinoma, Breast carcinoma, Renal clear cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Serous ovarian adenocarcinoma, Small cell lung carcinoma, Colorectal adenocarcinoma, Head and neck squamous cell carcinoma

Ensembl id ENSG00000204217
Mutated samples
Coding Sequence 59 (0.9%)
Protein Affecting 50 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all BMPR2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 8 7 1.90
Breast carcinoma Yes 7 5 0.44
Bladder carcinoma Yes 6 4 4.08
Head and neck squamous cell carcinoma Yes 5 4 1.07
Renal clear cell carcinoma Yes 3 3 0.72
Serous ovarian adenocarcinoma Yes 4 3 0.95
Lung adenocarcinoma Yes 2 2 0.51
Uterine corpus endometrioid carcinoma Yes 2 2 0.87
Small cell lung carcinoma Yes 2 2 2.90
Colorectal adenocarcinoma Yes 2 2 0.87
Stomach adenocarcinoma No 10 10 6.21
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 1 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence