IntOGen - BIRC6 gene cancer mutations in BLCA

BIRC6 is detected as a mutational cancer driver in Bladder Urothelial Carcinoma

BIRC6 reports in Bladder Urothelial Carcinoma (BLCA)

Methods
Mutation distribution

Cancer type details

Bladder Urothelial Carcinoma
Cohorts 8 Samples 905 Mutations 6,585,575 Driver genes 89

Gene details

BIRC6
Ensembl ID ENSG00000115760 Transcript ID ENST00000421745 Protein ID ENSP00000393596
Cohorts where is driver 3 Mutated samples 59 Mutated samples (%) 6.52 Mutations 108
Mode of action Ambiguous
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence