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BIRC6 has not been detected as a mutational cancer driver

BIRC6
Ensembl id ENSG00000115760
Mutated samples
Coding Sequence 220 (3.2%)
Protein Affecting 170 (2.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all BIRC6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 35 26 7.05
Lung adenocarcinoma No 25 25 6.39
Breast carcinoma No 25 21 1.83
Lung squamous cell carcinoma No 27 21 12.07
Head and neck squamous cell carcinoma No 17 15 4.00
Bladder carcinoma No 15 10 10.20
Uterine corpus endometrioid carcinoma No 16 10 4.35
Renal clear cell carcinoma No 10 9 2.16
Esophageal carcinoma No 7 7 4.79
Serous ovarian adenocarcinoma No 7 6 1.90
Stomach adenocarcinoma No 8 5 3.11
Glioblastoma multiforme No 6 5 1.32
Chronic lymphocytic leukemia No 9 3 1.03
Prostate adenocarcinoma No 2 2 0.82
Hepatocarcinoma No 3 2 2.22
Medulloblastoma No 3 1 0.48
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Pancreas adenocarcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence