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BCL11A is detected as a mutational cancer driver in 1 cancer type: Head and neck squamous cell carcinoma

BCL11A
Ensembl id ENSG00000119866
Mutated samples
Coding Sequence 124 (1.8%)
Protein Affecting 76 (1.1%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
HNSC C
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all BCL11A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 6 5 1.33
Cutaneous melanoma No 51 33 8.94
Lung squamous cell carcinoma No 10 8 4.60
Lung adenocarcinoma No 9 6 1.53
Glioblastoma multiforme No 6 6 1.58
Breast carcinoma No 8 4 0.35
Stomach adenocarcinoma No 5 3 1.86
Thyroid carcinoma No 2 2 0.62
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 3 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 4 1 0.34
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Esophageal carcinoma No 5 1 0.68
Hepatocarcinoma No 3 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 4 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence