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BAP1 is detected as a mutational cancer driver in 1 cancer type: Renal clear cell carcinoma and in the PAN-cancer analysis

BAP1
Ensembl id ENSG00000163930
Mutated samples
Coding Sequence 116 (1.7%)
Protein Affecting 85 (1.3%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
RCCC FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all BAP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Renal clear cell carcinoma Yes 43 39 9.35
Cutaneous melanoma Yes 15 7 1.90
Breast carcinoma Yes 7 6 0.52
Lung adenocarcinoma Yes 8 5 1.28
Bladder carcinoma Yes 5 4 4.08
Head and neck squamous cell carcinoma Yes 5 4 1.07
Stomach adenocarcinoma Yes 6 3 1.86
Esophageal carcinoma Yes 6 3 2.05
Serous ovarian adenocarcinoma Yes 3 2 0.63
Glioblastoma multiforme Yes 3 2 0.53
Uterine corpus endometrioid carcinoma No 5 5 2.17
Prostate adenocarcinoma No 2 1 0.41
Hepatocarcinoma No 1 1 1.11
Lung squamous cell carcinoma No 3 1 0.57
Thyroid carcinoma No 2 1 0.31
Chronic lymphocytic leukemia No 1 1 0.34
Neuroblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence