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ATP1A1 has not been detected as a mutational cancer driver

ATP1A1
Ensembl id ENSG00000163399
Mutated samples
Coding Sequence 52 (0.8%)
Protein Affecting 34 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP1A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Renal clear cell carcinoma No 7 6 1.44
Stomach adenocarcinoma No 5 5 3.11
Cutaneous melanoma No 13 4 1.08
Breast carcinoma No 4 3 0.26
Lung adenocarcinoma No 2 2 0.51
Bladder carcinoma No 4 2 2.04
Head and neck squamous cell carcinoma No 2 2 0.53
Hepatocarcinoma No 1 1 1.11
Lung squamous cell carcinoma No 2 1 0.57
Thyroid carcinoma No 2 1 0.31
Uterine corpus endometrioid carcinoma No 2 1 0.43
Chronic lymphocytic leukemia No 2 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence