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ATP13A5 has not been detected as a mutational cancer driver

ATP13A5
Ensembl id ENSG00000187527
Mutated samples
Coding Sequence 137 (2.0%)
Protein Affecting 99 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP13A5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 66 50 13.55
Lung adenocarcinoma No 9 8 2.05
Lung squamous cell carcinoma No 6 6 3.45
Breast carcinoma No 6 4 0.35
Renal clear cell carcinoma No 4 4 0.96
Stomach adenocarcinoma No 4 4 2.48
Small cell lung carcinoma No 5 4 5.80
Head and neck squamous cell carcinoma No 6 4 1.07
Prostate adenocarcinoma No 3 3 1.23
Colorectal adenocarcinoma No 3 3 1.31
Hepatocarcinoma No 3 2 2.22
Uterine corpus endometrioid carcinoma No 6 2 0.87
Serous ovarian adenocarcinoma No 3 2 0.63
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Bladder carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence