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ATG16L1 has not been detected as a mutational cancer driver

ATG16L1
Ensembl id ENSG00000085978
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 23 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATG16L1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 6 4 0.35
Cutaneous melanoma No 5 3 0.81
Uterine corpus endometrioid carcinoma No 3 3 1.30
Head and neck squamous cell carcinoma No 4 3 0.80
Lung adenocarcinoma No 3 2 0.51
Lung squamous cell carcinoma No 3 2 1.15
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 2 1 1.02
Acute myeloid leukemia No 2 1 0.51
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence