Top
ASPM is detected as a mutational cancer driver in 2 cancer types: Cutaneous melanoma, Esophageal carcinoma and in the PAN-cancer analysis

ASPM
Ensembl id ENSG00000066279
Mutated samples
Coding Sequence 233 (3.4%)
Protein Affecting 186 (2.7%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM F
ESCA F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ASPM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 45 35 9.49
Breast carcinoma Yes 19 16 1.39
Esophageal carcinoma Yes 7 7 4.79
Small cell lung carcinoma Yes 9 6 8.70
Serous ovarian adenocarcinoma Yes 4 3 0.95
Colorectal adenocarcinoma Yes 4 3 1.31
Lung adenocarcinoma No 40 35 8.95
Head and neck squamous cell carcinoma No 27 24 6.40
Lung squamous cell carcinoma No 18 14 8.05
Uterine corpus endometrioid carcinoma No 16 12 5.22
Stomach adenocarcinoma No 8 7 4.35
Bladder carcinoma No 8 6 6.12
Lower grade glioma No 4 4 2.37
Glioblastoma multiforme No 5 4 1.06
Renal clear cell carcinoma No 5 3 0.72
Prostate adenocarcinoma No 2 1 0.41
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 3 1 0.34
Multiple myeloma No 1 1 1.45
Thyroid carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence