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ARHGEF2 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

ARHGEF2
Ensembl id ENSG00000116584
Mutated samples
Coding Sequence 83 (1.2%)
Protein Affecting 45 (0.7%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARHGEF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 28 18 4.88
Lung squamous cell carcinoma No 9 7 4.02
Lung adenocarcinoma No 7 4 1.02
Breast carcinoma No 9 3 0.26
Uterine corpus endometrioid carcinoma No 5 3 1.30
Stomach adenocarcinoma No 4 2 1.24
Head and neck squamous cell carcinoma No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 2 1 1.02
Thyroid carcinoma No 2 1 0.31
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 4 1 0.44
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 2 0 0.00
Acute myeloid leukemia No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence