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APLF has not been detected as a mutational cancer driver

APLF
Ensembl id ENSG00000169621
Mutated samples
Coding Sequence 51 (0.8%)
Protein Affecting 26 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all APLF gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 9 7 1.87
Cutaneous melanoma No 8 5 1.36
Breast carcinoma No 6 3 0.26
Lung adenocarcinoma No 3 2 0.51
Hepatocarcinoma No 5 2 2.22
Lung squamous cell carcinoma No 3 2 1.15
Serous ovarian adenocarcinoma No 3 2 0.63
Renal clear cell carcinoma No 2 1 0.24
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Bladder carcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Stomach adenocarcinoma No 3 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence