ALK is detected as a mutational cancer driver in Non-Small Cell Lung Cancer
ALK reports in Non-Small Cell Lung Cancer (NSCLC)
Cancer type details
| Non-Small Cell Lung Cancer |
|---|
|
Cohorts
2
Samples 564 Mutations 22,065,649 Driver genes 48 |
Gene details
| ALK |
|---|
|
Ensembl ID
ENSG00000171094
Transcript ID ENST00000389048 Protein ID ENSP00000373700 |
|
Cohorts where is driver
1
Mutated samples 32 Mutated samples (%) 5.67 Mutations 44 |
| Mode of action Activating |
| Known driver True |
Method signals per Cohort
| Cohort | Methods | Samples | Samples (%) |
|---|
ClustL
HotMAPS
smRegions
Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed
mutations along the protein sequence.
| Mutation (GRCh38) | Protein Position | Samples | Samples (%) | Consequence |
|---|