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ALK is detected as a mutational cancer driver in 2 cancer types: Neuroblastoma, Uterine corpus endometrioid carcinoma

ALK
Ensembl id ENSG00000171094
Mutated samples
Coding Sequence 174 (2.6%)
Protein Affecting 125 (1.8%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
NB CF
UCEC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ALK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Neuroblastoma Yes 19 19 9.05
Uterine corpus endometrioid carcinoma Yes 8 8 3.48
Cutaneous melanoma No 37 22 5.96
Lung adenocarcinoma No 30 21 5.37
Head and neck squamous cell carcinoma No 9 8 2.13
Breast carcinoma No 9 6 0.52
Renal clear cell carcinoma No 6 6 1.44
Esophageal carcinoma No 8 6 4.11
Stomach adenocarcinoma No 6 4 2.48
Small cell lung carcinoma No 4 4 5.80
Colorectal adenocarcinoma No 6 4 1.75
Lung squamous cell carcinoma No 5 3 1.72
Non small cell lung carcinoma No 3 3 9.68
Serous ovarian adenocarcinoma No 3 3 0.95
Hepatocarcinoma No 4 2 2.22
Glioblastoma multiforme No 2 2 0.53
Bladder carcinoma No 2 1 1.02
Medulloblastoma No 1 1 0.48
Thyroid carcinoma No 2 1 0.31
Chronic lymphocytic leukemia No 9 1 0.34
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence