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ADAMTS3 has not been detected as a mutational cancer driver

ADAMTS3
Ensembl id ENSG00000156140
Mutated samples
Coding Sequence 114 (1.7%)
Protein Affecting 82 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ADAMTS3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 18 14 3.79
Lung adenocarcinoma No 12 12 3.07
Head and neck squamous cell carcinoma No 11 10 2.67
Lung squamous cell carcinoma No 10 7 4.02
Stomach adenocarcinoma No 9 7 4.35
Uterine corpus endometrioid carcinoma No 6 5 2.17
Bladder carcinoma No 4 4 4.08
Breast carcinoma No 9 4 0.35
Small cell lung carcinoma No 4 4 5.80
Esophageal carcinoma No 6 3 2.05
Prostate adenocarcinoma No 2 2 0.82
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 2 2 1.18
Glioblastoma multiforme No 2 2 0.53
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 1 1 0.24
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 3 1 0.44
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence