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WHSC1 is detected as a mutational cancer driver in 1 cancer type: Head and neck squamous cell carcinoma

WHSC1
Ensembl id ENSG00000109685
Mutated samples
Coding Sequence 101 (1.5%)
Protein Affecting 62 (0.9%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
HNSC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all WHSC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 12 10 2.67
Cutaneous melanoma No 23 17 4.61
Breast carcinoma No 10 8 0.70
Bladder carcinoma No 10 6 6.12
Lung adenocarcinoma No 5 4 1.02
Uterine corpus endometrioid carcinoma No 8 3 1.30
Esophageal carcinoma No 5 3 2.05
Medulloblastoma No 2 2 0.95
Renal clear cell carcinoma No 3 2 0.48
Serous ovarian adenocarcinoma No 5 2 0.63
Prostate adenocarcinoma No 2 1 0.41
Lung squamous cell carcinoma No 3 1 0.57
Stomach adenocarcinoma No 3 1 0.62
Small cell lung carcinoma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence