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VHL is detected as a mutational cancer driver in 1 Renal clear cell carcinoma project

Renal clear cell carcinoma
Projects 1
417 Samples
Coding sequence mutations (CSMs)
in driver genes 969
in all genes 41084
Protein affecting mutations (PAMs)
in driver genes 859
in all genes 20546
VHL
Ensembl id ENSG00000134086
Mutated samples
Coding Sequence 219 (52.5%)
Protein Affecting 216 (51.8%)
Mode of action Loss of function
Known driver Yes
Project Signals
RCCC_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Renal clear cell carcinoma projects in all VHL gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Kidney clear cell carcinoma TCGA Yes 219 216 51.80
The mutations needle plot shows the distribution of the observed VHL cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification