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TP53 is detected as a mutational cancer driver in 2 Small cell lung carcinoma projects

Small cell lung carcinoma
Projects 2
69 Samples
Coding sequence mutations (CSMs)
in driver genes 299
in all genes 22075
Protein affecting mutations (PAMs)
in driver genes 281
in all genes 14252
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 60 (87.0%)
Protein Affecting 59 (85.5%)
Mode of action Loss of function
Known driver Yes
Project Signals
SCLC_UKOLN F
SCLC_JHU F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Small cell lung carcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Small cell lung cancer Johns Hopkins University Yes 36 36 52.17
Small cell lung cancer University of Cologne Yes 24 23 33.33
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification