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TP53 is detected as a mutational cancer driver in 1 Hepatocarcinoma project

Hepatocarcinoma
Projects 2
90 Samples
Coding sequence mutations (CSMs)
in driver genes 151
in all genes 28172
Protein affecting mutations (PAMs)
in driver genes 104
in all genes 4873
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 16 (17.8%)
Protein Affecting 16 (17.8%)
Mode of action Loss of function
Known driver Yes
Project Signals
HC_ICGC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Hepatocarcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Liver Cancer ICGC obtained from AlexandrovEtAl Yes 15 15 16.67
Liver cancer IARC No 1 1 1.11
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification