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TP53 is detected as a mutational cancer driver in 1 Bladder carcinoma project

Bladder carcinoma
Projects 1
98 Samples
Coding sequence mutations (CSMs)
in driver genes 954
in all genes 42075
Protein affecting mutations (PAMs)
in driver genes 816
in all genes 20707
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 49 (50.0%)
Protein Affecting 49 (50.0%)
Mode of action Loss of function
Known driver Yes
Project Signals
BLCA_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Bladder carcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder urothelial carcinoma TCGA Yes 49 49 50.00
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification