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TP53 is detected as a mutational cancer driver in 1 Acute lymphocytic leukemia project

Acute lymphocytic leukemia
Projects 3
122 Samples
Coding sequence mutations (CSMs)
in driver genes 43
in all genes 2592
Protein affecting mutations (PAMs)
in driver genes 42
in all genes 1268
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 11 (9.0%)
Protein Affecting 10 (8.2%)
Mode of action Loss of function
Known driver Yes
Project Signals
ALL_STJUDE F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Acute lymphocytic leukemia projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute Lymphoyd Leukemia St. Jude Hospital Memphis obtained from AlexandrovEtAl Yes 11 10 8.20
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification