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TMEM57 has not been detected as a mutational cancer driver

TMEM57
Ensembl id ENSG00000204178
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 26 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TMEM57 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 5 5 0.44
Bladder carcinoma No 3 3 3.06
Small cell lung carcinoma No 3 3 4.35
Colorectal adenocarcinoma No 3 3 1.31
Lung adenocarcinoma No 3 2 0.51
Cutaneous melanoma No 10 2 0.54
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 3 1 0.57
Uterine corpus endometrioid carcinoma No 1 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence