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SMAD4 mutations in 1 Lung adenocarcinoma project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Lung adenocarcinoma
Projects 2
391 Samples
Coding sequence mutations (CSMs)
in driver genes 1564
in all genes 112729
Protein affecting mutations (PAMs)
in driver genes 1381
in all genes 61402
SMAD4
Ensembl id ENSG00000141646
Mutated samples
Coding Sequence 12 (3.1%)
Protein Affecting 9 (2.3%)
Mode of action Loss of function
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Lung adenocarcinoma projects in all SMAD4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Washington University Yes 2 2 0.51
Lung adenocarcinoma TCGA No 10 7 1.79
The mutations needle plot shows the distribution of the observed SMAD4 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification