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PRKAR1A is detected as a mutational cancer driver in 1 Medulloblastoma project

Medulloblastoma
Projects 2
210 Samples
Coding sequence mutations (CSMs)
in driver genes 161
in all genes 8146
Protein affecting mutations (PAMs)
in driver genes 159
in all genes 2132
PRKAR1A
Ensembl id ENSG00000108946
Mutated samples
Coding Sequence 3 (1.4%)
Protein Affecting 3 (1.4%)
Mode of action Loss of function
Known driver Yes
Project Signals
MB_SANGER F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Medulloblastoma projects in all PRKAR1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Medulloblastoma tumors obtained from Alexandrov et al. Yes 3 3 1.43
The mutations needle plot shows the distribution of the observed PRKAR1A cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification