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PPM1D is detected as a mutational cancer driver in 1 Thyroid carcinoma project

Thyroid carcinoma
Projects 1
322 Samples
Coding sequence mutations (CSMs)
in driver genes 316
in all genes 10749
Protein affecting mutations (PAMs)
in driver genes 305
in all genes 5121
PPM1D
Ensembl id ENSG00000170836
Mutated samples
Coding Sequence 5 (1.6%)
Protein Affecting 5 (1.6%)
Mode of action Loss of function
Known driver No
Project Signals
THCA_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Thyroid carcinoma projects in all PPM1D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Thyroid Cancer TCGA obtained from Synapse Yes 5 5 1.55
The mutations needle plot shows the distribution of the observed PPM1D cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification