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NRAS is detected as a mutational cancer driver in 1 Acute myeloid leukemia project

Acute myeloid leukemia
Projects 1
196 Samples
Coding sequence mutations (CSMs)
in driver genes 409
in all genes 3330
Protein affecting mutations (PAMs)
in driver genes 376
in all genes 1798
NRAS
Ensembl id ENSG00000213281
Mutated samples
Coding Sequence 15 (7.7%)
Protein Affecting 15 (7.7%)
Mode of action Activating
Known driver Yes
Project Signals
AML_TCGA RFC
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Acute myeloid leukemia projects in all NRAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute myeloid leukemia TCGA Yes 15 15 7.65
The mutations needle plot shows the distribution of the observed NRAS cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification