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NF2 mutations in 1 Lower grade glioma project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Lower grade glioma
Projects 1
169 Samples
Coding sequence mutations (CSMs)
in driver genes 595
in all genes 11911
Protein affecting mutations (PAMs)
in driver genes 566
in all genes 5986
NF2
Ensembl id ENSG00000186575
Mutated samples
Coding Sequence 2 (1.2%)
Protein Affecting 2 (1.2%)
Mode of action Loss of function
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Lower grade glioma projects in all NF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Low Grade Glioma TCGA Yes 2 2 1.18
The mutations needle plot shows the distribution of the observed NF2 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification