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BRAF is detected as a mutational cancer driver in 1 Thyroid carcinoma project

Thyroid carcinoma
Projects 1
322 Samples
Coding sequence mutations (CSMs)
in driver genes 316
in all genes 10749
Protein affecting mutations (PAMs)
in driver genes 305
in all genes 5121
BRAF
Ensembl id ENSG00000157764
Mutated samples
Coding Sequence 183 (56.8%)
Protein Affecting 182 (56.5%)
Mode of action Activating
Known driver Yes
Project Signals
THCA_TCGA RFC
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Thyroid carcinoma projects in all BRAF gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Thyroid Cancer TCGA obtained from Synapse Yes 183 182 56.52
The mutations needle plot shows the distribution of the observed BRAF cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification