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29 mutational cancer drivers have been detected in this of Stomach adenocarcinoma (STAD) project from Pfizer. The most mutated drivers are: TP53, ARFGEF1, PTEN, ARID1A, ARID4A, etc.



Gastric cancer Pfizer
STAD Stomach adenocarcinoma
22 Samples
Driver / Mut. genes29 / 7027
Pfizer
PMID:22037554
Coding sequence mutations (CSMs)
in driver genes 110
in all genes 10096
Protein affecting mutations (PAMs)
in driver genes 90
in all genes 4064
This driver cloud represents the most recurrently mutated cancer driver genes in the Gastric cancer Pfizer dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Gastric cancer Pfizer dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 9 9 40.91
ARFGEF1 ENSG00000066777 5 3 13.64
PTEN ENSG00000171862 6 6 27.27
ARID1A ENSG00000117713 6 6 27.27
ARID4A ENSG00000032219 3 3 13.64
ACVR2A ENSG00000121989 4 4 18.18
RPL22 ENSG00000116251 3 3 13.64
MACF1 ENSG00000127603 3 2 9.09
BRCA1 ENSG00000012048 2 2 9.09
NUP98 ENSG00000110713 3 2 9.09
CTNNB1 ENSG00000168036 2 2 9.09
PIK3CA ENSG00000121879 3 3 13.64
CHD3 ENSG00000170004 2 2 9.09
NSD1 ENSG00000165671 3 2 9.09
CAD ENSG00000084774 2 2 9.09
APC ENSG00000134982 3 3 13.64
ARID1B ENSG00000049618 2 2 9.09
ASH1L ENSG00000116539 3 2 9.09
SOS2 ENSG00000100485 3 2 9.09
MYH11 ENSG00000133392 2 2 9.09
AKAP9 ENSG00000127914 2 2 9.09
ANK3 ENSG00000151150 3 3 13.64
DDX5 ENSG00000108654 2 2 9.09
ATRX ENSG00000085224 2 2 9.09
SIN3A ENSG00000169375 2 2 9.09
NR4A2 ENSG00000153234 2 2 9.09
TJP2 ENSG00000119139 2 2 9.09
TP53BP1 ENSG00000067369 2 2 9.09
CDH1 ENSG00000039068 2 2 9.09