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29 mutational cancer drivers have been detected in this of Small cell lung carcinoma (SCLC) project from University of Cologne. The most mutated drivers are: TP53, RB1, MNDA, PTEN, ASPM, etc.



Small cell lung cancer University of Cologne
SCLC Small cell lung carcinoma
27 Samples
Driver / Mut. genes29 / 7107
University of Cologne
PMID:22941188
Coding sequence mutations (CSMs)
in driver genes 133
in all genes 11043
Protein affecting mutations (PAMs)
in driver genes 117
in all genes 6254
This driver cloud represents the most recurrently mutated cancer driver genes in the Small cell lung cancer University of Cologne dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Small cell lung cancer University of Cologne dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 24 23 85.19
RB1 ENSG00000139687 18 18 66.67
MNDA ENSG00000163563 3 3 11.11
PTEN ENSG00000171862 3 3 11.11
ASPM ENSG00000066279 6 3 11.11
TAF1 ENSG00000147133 5 3 11.11
NOTCH1 ENSG00000148400 3 3 11.11
ANK3 ENSG00000151150 4 3 11.11
MLL ENSG00000118058 4 4 14.81
ARID1B ENSG00000049618 4 3 11.11
PTPRU ENSG00000060656 4 4 14.81
FAM123B ENSG00000184675 4 3 11.11
MLL3 ENSG00000055609 3 3 11.11
NUP107 ENSG00000111581 3 2 7.41
ITSN1 ENSG00000205726 3 2 7.41
HGF ENSG00000019991 3 3 11.11
ATR ENSG00000175054 3 2 7.41
ATRX ENSG00000085224 3 2 7.41
EP300 ENSG00000100393 3 3 11.11
EIF2AK3 ENSG00000172071 2 2 7.41
BMPR2 ENSG00000204217 2 2 7.41
CREBBP ENSG00000005339 2 2 7.41
ASH1L ENSG00000116539 2 2 7.41
NF1 ENSG00000196712 2 2 7.41
SPTAN1 ENSG00000197694 2 2 7.41
NR4A2 ENSG00000153234 2 2 7.41
MYB ENSG00000118513 2 2 7.41
RAD21 ENSG00000164754 2 2 7.41
MED12 ENSG00000184634 2 2 7.41