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45 mutational cancer drivers have been detected in this of Small cell lung carcinoma (SCLC) project from Johns Hopkins University. The most mutated drivers are: TP53, RB1, BCLAF1, AHNAK, KALRN, etc.



Small cell lung cancer Johns Hopkins University
SCLC Small cell lung carcinoma
42 Samples
Driver / Mut. genes45 / 7220
Johns Hopkins University
PMID:22941189
Coding sequence mutations (CSMs)
in driver genes 166
in all genes 11032
Protein affecting mutations (PAMs)
in driver genes 164
in all genes 7998
This driver cloud represents the most recurrently mutated cancer driver genes in the Small cell lung cancer Johns Hopkins University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Small cell lung cancer Johns Hopkins University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 36 36 85.71
RB1 ENSG00000139687 19 19 45.24
BCLAF1 ENSG00000029363 5 5 11.90
AHNAK ENSG00000124942 4 3 7.14
KALRN ENSG00000160145 4 4 9.52
MTOR ENSG00000198793 4 4 9.52
EP300 ENSG00000100393 4 4 9.52
FAT1 ENSG00000083857 4 4 9.52
ANK3 ENSG00000151150 4 4 9.52
TAF1 ENSG00000147133 3 3 7.14
SOS1 ENSG00000115904 3 3 7.14
ASPM ENSG00000066279 3 3 7.14
ATR ENSG00000175054 3 3 7.14
MLL2 ENSG00000167548 3 3 7.14
TJP1 ENSG00000104067 2 2 4.76
SIN3A ENSG00000169375 3 2 4.76
BNC2 ENSG00000173068 3 3 7.14
FAM123B ENSG00000184675 2 2 4.76
PIK3CA ENSG00000121879 2 2 4.76
EIF2AK3 ENSG00000172071 2 2 4.76
FN1 ENSG00000115414 2 2 4.76
BRWD1 ENSG00000185658 2 2 4.76
TBX3 ENSG00000135111 2 2 4.76
KDM6A ENSG00000147050 2 2 4.76
HGF ENSG00000019991 2 2 4.76
CHEK2 ENSG00000183765 2 2 4.76
CREBBP ENSG00000005339 2 2 4.76
DICER1 ENSG00000100697 2 2 4.76
CCT5 ENSG00000150753 2 2 4.76
MSR1 ENSG00000038945 2 2 4.76
SOS2 ENSG00000100485 2 2 4.76
ZC3H11A ENSG00000058673 2 2 4.76
CLSPN ENSG00000092853 2 2 4.76
CHD1L ENSG00000131778 2 2 4.76
AKAP9 ENSG00000127914 2 2 4.76
ARID1A ENSG00000117713 2 2 4.76
BAZ2B ENSG00000123636 2 2 4.76
CDK12 ENSG00000167258 2 2 4.76
GNAS ENSG00000087460 2 2 4.76
NCKAP1 ENSG00000061676 2 2 4.76
ARID2 ENSG00000189079 2 2 4.76
HSP90AB1 ENSG00000096384 2 2 4.76
AHR ENSG00000106546 2 2 4.76
PTEN ENSG00000171862 2 2 4.76
MED12 ENSG00000184634 2 2 4.76