PIK3CA is detected as a mutational cancer driver
PIK3CA reports
Gene details
PIK3CA |
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Ensembl ID
ENSG00000121879
Transcript ID ENST00000263967 Protein ID ENSP00000263967 |
Cancer types where is driver
43
Cohorts where is driver 107 Mutated samples 2,446 Mutations 3,012 |
Mode of action Ambiguous |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
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BLCA (Bladder Urothelial Carcinoma) | 9603 | 933 | 9.72 |
BRCA (Invasive Breast Carcinoma) | 9603 | 361 | 3.76 |
CESC (Cervical Squamous Cell Carcinoma) | 9603 | 646 | 6.73 |
COREAD (Colorectal Adenocarcinoma) | 9603 | 709 | 7.38 |
ESCA (Esophageal Adenocarcinoma) | 9603 | 588 | 6.12 |
G (Glioblastoma Multiforme) | 9603 | 1097 | 11.42 |
HNSC (Head and Neck Squamous Cell Carcinoma) | 9603 | 728 | 7.58 |
LGG (Low-Grade Glioma, NOS) | 9603 | 2806 | 29.22 |
PRAD (Prostate Adenocarcinoma) | 9603 | 2325 | 24.21 |
ST (Stomach Adenocarcinoma) | 9603 | 1356 | 14.12 |
UCEC (Endometrial Carcinoma) | 9603 | 774 | 8.06 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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