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16 mutational cancer drivers have been detected in this of Medulloblastoma (MB) project from Sanger Institute. The most mutated drivers are: DDX3X, CTNNB1, PTCH1, SMARCA4, SMO, etc.



Medulloblastoma tumors obtained from Alexandrov et al.
MB Medulloblastoma
100 Samples
Driver / Mut. genes16 / 5917
Sanger Institute
doi:10.1038/nature12477
Coding sequence mutations (CSMs)
in driver genes 83
in all genes 6958
Protein affecting mutations (PAMs)
in driver genes 82
in all genes 1320
This driver cloud represents the most recurrently mutated cancer driver genes in the Medulloblastoma tumors obtained from Alexandrov et al. dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Medulloblastoma tumors obtained from Alexandrov et al. dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
DDX3X ENSG00000215301 15 15 15.00
CTNNB1 ENSG00000168036 11 11 11.00
PTCH1 ENSG00000185920 6 6 6.00
SMARCA4 ENSG00000127616 5 5 5.00
SMO ENSG00000128602 6 6 6.00
CREBBP ENSG00000005339 5 5 5.00
PRKAR1A ENSG00000108946 3 3 3.00
FBXW7 ENSG00000109670 3 3 3.00
MLL2 ENSG00000167548 4 4 4.00
TCF4 ENSG00000196628 3 3 3.00
PIK3CA ENSG00000121879 3 3 3.00
ARID1A ENSG00000117713 3 3 3.00
MLL3 ENSG00000055609 2 2 2.00
CCAR1 ENSG00000060339 2 2 2.00
ARID2 ENSG00000189079 2 2 2.00
FMR1 ENSG00000102081 2 2 2.00