PTPN11 is detected as a mutational cancer driver
PTPN11 reports
Gene details
PTPN11 |
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Ensembl ID
ENSG00000179295
Transcript ID ENST00000635625 Protein ID ENSP00000489597 |
Cancer types where is driver
9
Cohorts where is driver 16 Mutated samples 107 Mutations 352 |
Mode of action Activating |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
LK (Acute Myeloid Leukemia) | 5364 | 228 | 4.25 |
MM (Plasma Cell Myeloma) | 5364 | 60 | 1.12 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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