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23 mutational cancer drivers have been detected in this of Lung adenocarcinoma (LUAD) project from Washington University. The most mutated drivers are: TP53, KRAS, STK11, EGFR, RB1, etc.



Lung adenocarcinoma Washington University
LUAD Lung adenocarcinoma
163 Samples
Driver / Mut. genes23 / 547
Washington University
PMID:18948947
Coding sequence mutations (CSMs)
in driver genes 247
in all genes 1401
Protein affecting mutations (PAMs)
in driver genes 236
in all genes 999
This driver cloud represents the most recurrently mutated cancer driver genes in the Lung adenocarcinoma Washington University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Lung adenocarcinoma Washington University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 64 63 38.65
KRAS ENSG00000133703 60 60 36.81
STK11 ENSG00000118046 34 34 20.86
EGFR ENSG00000146648 30 21 12.88
RB1 ENSG00000139687 7 7 4.29
NRAS ENSG00000213281 3 3 1.84
MAP4K1 ENSG00000104814 3 3 1.84
SMAD4 ENSG00000141646 2 2 1.23
BRAF ENSG00000157764 3 3 1.84
MAP3K4 ENSG00000085511 3 3 1.84
PTPN11 ENSG00000179295 3 3 1.84
MET ENSG00000105976 3 3 1.84
CTNNB1 ENSG00000168036 2 2 1.23
MLL ENSG00000118058 2 2 1.23
BAP1 ENSG00000163930 2 2 1.23
MAP4K3 ENSG00000011566 2 2 1.23
FBXW7 ENSG00000109670 2 2 1.23
FGFR2 ENSG00000066468 2 2 1.23
AKT1 ENSG00000142208 2 2 1.23
EIF4G1 ENSG00000114867 2 2 1.23
MYB ENSG00000118513 2 2 1.23
CDK12 ENSG00000167258 2 2 1.23
ACVR1B ENSG00000135503 2 2 1.23