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54 mutational cancer drivers have been detected in this of Head and neck squamous cell carcinoma (HNSC) project from Broad Institute. The most mutated drivers are: TP53, FAT1, CDKN2A, PIK3CA, NSD1, etc.



Head and neck squamous cell carcinoma BROAD
HNSC Head and neck squamous cell carcinoma
74 Samples
Driver / Mut. genes54 / 8596
Broad Institute
Coding sequence mutations (CSMs)
in driver genes 215
in all genes 13784
Protein affecting mutations (PAMs)
in driver genes 193
in all genes 7217
This driver cloud represents the most recurrently mutated cancer driver genes in the Head and neck squamous cell carcinoma BROAD dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Head and neck squamous cell carcinoma BROAD dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 39 39 52.70
FAT1 ENSG00000083857 8 8 10.81
CDKN2A ENSG00000147889 8 8 10.81
PIK3CA ENSG00000121879 6 6 8.11
NSD1 ENSG00000165671 6 5 6.76
CASP8 ENSG00000064012 6 6 8.11
IRF6 ENSG00000117595 4 4 5.41
HRAS ENSG00000174775 4 4 5.41
ATRX ENSG00000085224 6 3 4.05
ATR ENSG00000175054 3 2 2.70
NF1 ENSG00000196712 5 3 4.05
HLA-A ENSG00000206503 3 3 4.05
EZH2 ENSG00000106462 4 3 4.05
DDX3X ENSG00000215301 3 3 4.05
APC ENSG00000134982 4 2 2.70
KALRN ENSG00000160145 4 2 2.70
EP300 ENSG00000100393 4 3 4.05
EIF2C3 ENSG00000126070 4 3 4.05
PRPF8 ENSG00000174231 3 2 2.70
PCDH18 ENSG00000189184 3 2 2.70
DICER1 ENSG00000100697 2 2 2.70
BPTF ENSG00000171634 3 2 2.70
BRCA1 ENSG00000012048 2 2 2.70
ARFGEF2 ENSG00000124198 3 2 2.70
COL1A1 ENSG00000108821 3 2 2.70
GNAS ENSG00000087460 3 3 4.05
ATM ENSG00000149311 3 2 2.70
LPHN2 ENSG00000117114 2 2 2.70
CDH1 ENSG00000039068 3 3 4.05
RHOA ENSG00000067560 2 2 2.70
CUL3 ENSG00000036257 2 2 2.70
TBL1XR1 ENSG00000177565 2 2 2.70
ELF1 ENSG00000120690 2 2 2.70
PBRM1 ENSG00000163939 2 2 2.70
FN1 ENSG00000115414 2 2 2.70
PIK3R1 ENSG00000145675 2 2 2.70
TRIO ENSG00000038382 2 2 2.70
TGFBR2 ENSG00000163513 2 2 2.70
CLASP2 ENSG00000163539 2 2 2.70
ARID1B ENSG00000049618 2 2 2.70
MAP4K3 ENSG00000011566 2 2 2.70
SMARCA4 ENSG00000127616 2 2 2.70
TFDP2 ENSG00000114126 2 2 2.70
FOXP1 ENSG00000114861 2 2 2.70
DNMT3A ENSG00000119772 2 2 2.70
G3BP2 ENSG00000138757 2 2 2.70
MTOR ENSG00000198793 2 2 2.70
SIN3A ENSG00000169375 2 2 2.70
BAZ2B ENSG00000123636 2 2 2.70
CDK12 ENSG00000167258 2 2 2.70
BNC2 ENSG00000173068 2 2 2.70
NCKAP1 ENSG00000061676 2 2 2.70
EGFR ENSG00000146648 2 2 2.70
CHD9 ENSG00000177200 2 2 2.70