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28 mutational cancer drivers have been detected in this of Hepatocarcinoma (HC) project from International Cancer Genome Consortium. The most mutated drivers are: TP53, CTNNB1, NFE2L2, MLL3, MACF1, etc.



Liver Cancer ICGC obtained from AlexandrovEtAl
HC Hepatocarcinoma
66 Samples
Driver / Mut. genes28 / 16250
International Cancer Genome Consortium
doi:10.1038/nature12477
Coding sequence mutations (CSMs)
in driver genes 132
in all genes 26908
Protein affecting mutations (PAMs)
in driver genes 85
in all genes 3975
This driver cloud represents the most recurrently mutated cancer driver genes in the Liver Cancer ICGC obtained from AlexandrovEtAl dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Liver Cancer ICGC obtained from AlexandrovEtAl dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 15 15 22.73
CTNNB1 ENSG00000168036 10 8 12.12
NFE2L2 ENSG00000116044 9 2 3.03
MLL3 ENSG00000055609 7 3 4.55
MACF1 ENSG00000127603 6 2 3.03
SETDB1 ENSG00000143379 4 3 4.55
TBL1XR1 ENSG00000177565 5 2 3.03
NF1 ENSG00000196712 4 2 3.03
ATRX ENSG00000085224 5 2 3.03
ARID2 ENSG00000189079 4 3 4.55
ACVR2A ENSG00000121989 4 3 4.55
PBRM1 ENSG00000163939 4 3 4.55
ITSN1 ENSG00000205726 4 2 3.03
RTN4 ENSG00000115310 4 2 3.03
CEP290 ENSG00000198707 4 2 3.03
SF3B1 ENSG00000115524 4 2 3.03
PIK3CA ENSG00000121879 3 2 3.03
FLT3 ENSG00000122025 3 2 3.03
APC ENSG00000134982 3 2 3.03
ARID1B ENSG00000049618 3 2 3.03
ASH1L ENSG00000116539 3 2 3.03
ARHGAP35 ENSG00000160007 3 3 4.55
PTEN ENSG00000171862 3 3 4.55
IDH1 ENSG00000138413 2 2 3.03
BPTF ENSG00000171634 2 2 3.03
BLM ENSG00000197299 2 2 3.03
CNOT1 ENSG00000125107 2 2 3.03
MYH10 ENSG00000133026 2 2 3.03