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75 mutational cancer drivers have been detected in this of Glioblastoma multiforme (GBM) project from The Cancer Genome Atlas. The most mutated drivers are: EGFR, TP53, PTEN, NF1, PIK3CA, etc.



Glioblastoma multiforme TCGA
GBM Glioblastoma multiforme
290 Samples
Driver / Mut. genes75 / 13578
The Cancer Genome Atlas
doi:10.1038/nature07385
Coding sequence mutations (CSMs)
in driver genes 717
in all genes 30647
Protein affecting mutations (PAMs)
in driver genes 645
in all genes 15894
This driver cloud represents the most recurrently mutated cancer driver genes in the Glioblastoma multiforme TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Glioblastoma multiforme TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
EGFR ENSG00000146648 79 74 25.52
TP53 ENSG00000141510 83 81 27.93
PTEN ENSG00000171862 89 89 30.69
NF1 ENSG00000196712 34 31 10.69
PIK3CA ENSG00000121879 32 28 9.66
PIK3R1 ENSG00000145675 33 29 10.00
RB1 ENSG00000139687 25 24 8.28
ATRX ENSG00000085224 18 15 5.17
STAG2 ENSG00000101972 16 12 4.14
IDH1 ENSG00000138413 15 15 5.17
ZNF814 ENSG00000204514 10 10 3.45
CHD8 ENSG00000100888 10 10 3.45
KDR ENSG00000128052 8 8 2.76
RPL5 ENSG00000122406 8 8 2.76
RPSAP58 ENSG00000205246 8 8 2.76
BRAF ENSG00000157764 7 6 2.07
PTPN11 ENSG00000179295 5 5 1.72
AKAP9 ENSG00000127914 5 5 1.72
BPTF ENSG00000171634 6 2 0.69
MEN1 ENSG00000133895 5 3 1.03
CLOCK ENSG00000134852 5 3 1.03
CAD ENSG00000084774 5 3 1.03
FAT1 ENSG00000083857 5 3 1.03
MLL ENSG00000118058 4 3 1.03
EZH2 ENSG00000106462 4 3 1.03
PIK3CB ENSG00000051382 3 3 1.03
SOX9 ENSG00000125398 4 3 1.03
TJP1 ENSG00000104067 4 3 1.03
ARFGEF2 ENSG00000124198 3 3 1.03
AQR ENSG00000021776 3 3 1.03
ARID1A ENSG00000117713 4 2 0.69
CASP1 ENSG00000137752 4 2 0.69
CNOT1 ENSG00000125107 4 2 0.69
ANK3 ENSG00000151150 4 2 0.69
MAX ENSG00000125952 3 2 0.69
PCDH18 ENSG00000189184 3 2 0.69
BAP1 ENSG00000163930 3 2 0.69
FN1 ENSG00000115414 3 3 1.03
CUL1 ENSG00000055130 3 3 1.03
MAP3K4 ENSG00000085511 2 2 0.69
KDM6A ENSG00000147050 3 3 1.03
NEDD4L ENSG00000049759 3 2 0.69
SOS1 ENSG00000115904 3 3 1.03
MAP4K3 ENSG00000011566 3 3 1.03
PAX5 ENSG00000196092 3 3 1.03
NCF2 ENSG00000116701 3 3 1.03
CSDE1 ENSG00000009307 3 2 0.69
ADAM10 ENSG00000137845 3 2 0.69
SPTAN1 ENSG00000197694 3 3 1.03
BRCA1 ENSG00000012048 3 3 1.03
MET ENSG00000105976 2 2 0.69
PRPF8 ENSG00000174231 3 2 0.69
HSP90AB1 ENSG00000096384 3 2 0.69
WT1 ENSG00000184937 3 2 0.69
HDAC9 ENSG00000048052 3 2 0.69
NFATC4 ENSG00000100968 2 2 0.69
CLTC ENSG00000141367 2 2 0.69
PBRM1 ENSG00000163939 2 2 0.69
NUP107 ENSG00000111581 2 2 0.69
TRIO ENSG00000038382 2 2 0.69
TGFBR2 ENSG00000163513 2 2 0.69
CARM1 ENSG00000142453 2 2 0.69
DIS3 ENSG00000083520 2 2 0.69
ARHGAP35 ENSG00000160007 2 2 0.69
KALRN ENSG00000160145 2 2 0.69
SIN3A ENSG00000169375 2 2 0.69
LRP6 ENSG00000070018 2 2 0.69
NCOR1 ENSG00000141027 2 2 0.69
KDM5C ENSG00000126012 2 2 0.69
NR2F2 ENSG00000185551 2 2 0.69
ARID2 ENSG00000189079 2 2 0.69
ARHGEF6 ENSG00000129675 2 2 0.69
KRAS ENSG00000133703 2 2 0.69
ACAD8 ENSG00000151498 2 2 0.69
SF3B1 ENSG00000115524 2 2 0.69