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10 mutational cancer drivers have been detected in this of Diffuse B cell lymphoma (DLBC) project from Sanger Institute. The most mutated drivers are: MYC, CREBBP, SMARCA4, FBXO11, TP53, etc.



Difuse B cell lymphoma obtained from AlexandrovEtAl
DLBC Diffuse B cell lymphoma
23 Samples
Driver / Mut. genes10 / 4595
Sanger Institute
doi:10.1038/nature12477
Coding sequence mutations (CSMs)
in driver genes 74
in all genes 6097
Protein affecting mutations (PAMs)
in driver genes 52
in all genes 1034
This driver cloud represents the most recurrently mutated cancer driver genes in the Difuse B cell lymphoma obtained from AlexandrovEtAl dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Difuse B cell lymphoma obtained from AlexandrovEtAl dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
MYC ENSG00000136997 10 9 39.13
CREBBP ENSG00000005339 5 5 21.74
SMARCA4 ENSG00000127616 6 6 26.09
FBXO11 ENSG00000138081 6 5 21.74
TP53 ENSG00000141510 6 6 26.09
ACTB ENSG00000075624 2 2 8.70
ARID1A ENSG00000117713 2 2 8.70
MLL2 ENSG00000167548 2 2 8.70
AKAP9 ENSG00000127914 2 2 8.70
CHD4 ENSG00000111642 2 2 8.70